By Ramana S. Moorthy MD
Starts with an in-depth evaluate of immunemedicated eye ailment, summarizing easy immunologic suggestions, ocular immune responses and targeted themes in ocular immunology. Discusses the scientific method of uveitis and experiences noninfectious (autoimmune) and infectious kinds of uveitis, with an improved part on viral uveitis and new fabric on infectious and noninfectious scleritis. improved detection of infectious brokers via immunologic and genetic tools and new biologic therapeutics are certain. additionally covers endophthalmitis, masquerade syndromes, problems of uveitis and ocular features of AIDS. encompasses a variety of new colour photos. significant revision 2011-2012
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Additional info for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)
Hal/and GN, Wi/he/mus KR. eds. Ocular Infection and Imm unity. ) inhi bitors does diminish the onset of mild CME after cataract surgery, and both top ical and systemic nonsteroidal anti · inflammatory dr ug (NSAID) therapy might be efficacious in the treatment of persistent CME. Systemic NSAlD therapy is effective ;/1 treating reCllr· rent episcJeritis and mild cases of scleritis. Prostaglandins an d other eicosanoids indisputably playa major rol e in the physiology of the eye. reachi ng far beyond their putative participation as mediators of in flammation.
For example, prostaglandin E, regulates the alternative (uveoscleral) outfl ow pathway for aqueous humo r, perhaps explaining why intraocular pressure (lOP) is dimi nished in some inflamed eyes. Drugs such as lata noprost. a prostaglandin F2u analogue. may act with a similar mechanism. The prod ucts of the other major pathway of AA metabolism, th e S-Iipoxygenase path way. are also numerous, and some of them are extremely poten t medi ators of the inflam matory response. Derivatives of S-lipoxyge nase, an enzyme fo und main ly in granu locytes CHAPTER 1: Basic Concepts in Immunology .
25 Histamine Histamine is prese nt in the granules of mast cells and basoph ils, and it is actively secreted fro m this source following exposure of cells to a w id e range of stimuli. Histamine acts by bin ding to 1 of at least 3 known types of receptors that are differentially present on target cells. The best-studied pathway for degranulation is antigen cross-linking of IgE bound to mast -cell Fc IgE receptors, but many other inflammatory stimuli can stimulate secretion, including complement, direct membrane injur y, and certain drugs.
2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course) by Ramana S. Moorthy MD