Affinity Capillary Electrophoresis in Pharmaceutics and by Reinhard H. H. Neubert, Hans-Hermann Ruttinger PDF

By Reinhard H. H. Neubert, Hans-Hermann Ruttinger

ISBN-10: 0824709519

ISBN-13: 9780824709518

The authors provide options to discover and symbolize interactions among medicinal drugs, drug autos, and organic membranes to facilitate advancements in managed drug supply and concentrating on. The booklet comprises present purposes and approaches to spot binding constants among medicinal drugs, organic constructions, proteins, nucleic acids, and plasmids, bring up drug bioavailability, improve the permeability, solubility, power, and serve as of drug formulations, study protein-protein exchanges and reactions, and calculate pKa values.

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Hansen. Electrophoresis 19 (1998), 2179. J. T. Hansen. J. Pharm. Biomed. Anal. 15 (1997), 1077. T. Okada. J. Chromatogr. A 771 (1997), 275. © 2003 by Marcel Dekker, Inc. 2 Theory of Affinity Electrophoresis Hans-Hermann Ru¨ttinger Martin-Luther-University Halle-Wittenberg, Halle, Germany I. INTRODUCTION More or less specific noncovalent molecular interactions are ubiquitous in biological systems. Signal transduction such as hormone–receptor binding, transcription of hereditary information, enzyme substrate binding, and regulation of enzyme activity are only few examples.

Illustration, two binding sites are assumed. Binding of a ligand to site 1 leads to SL(1), controlled by the microscopic equilibrium constant k1, the first occupation of binding site 2 yields SL(2). Both forms of SL can bind a second ligand, leading to the same product (SL2): k1 S k2 \] ϩL SL(2) ` ϩL k21 SL(1) ϩL \] k12 ` SL2 ϩL The resultant different complexes with the same stoichiometry [SL(1) and SL(2)] generally can’t be separated by electrophoresis because of the same size and charge. Only the macroscopic equilibrium constants K1 and K2 can be derived from electrophoresis data.

Some correlations are given in Chapters 5 and 6. Equations (49) to (52) are derived for the simple case in which only one surfactant forms one type of micelles. Depending on surfactant concentration and other buffer constituents, a more or less complicated mixture of micelles differing in form and/or composition coexist in the buffer. All of these micelles may exhibit different partition behavior in relation to a certain © 2003 by Marcel Dekker, Inc. substrate and have at least a different micellar mobility.

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Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics by Reinhard H. H. Neubert, Hans-Hermann Ruttinger

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