Download e-book for iPad: Age-Related Macular Degeneration by Jennifer I. Lim

By Jennifer I. Lim

ISBN-10: 082470682X

ISBN-13: 9780824706821

ISBN-10: 0824744039

ISBN-13: 9780824744038

This reference showcases exudative and nonexudative AMD remedy thoughts utilizing argon and diode lasers, submacular and macular translocation surgical procedure, photodynamic treatment, radiation, feeder vessel remedy, thermotherapy, and antiangiogenesis medicinal drugs. together with one hundred sixty colour illustrations, Age-Related Macular Degeneration will gain medical ophthalmologists, pathologists, physiologists, and pharmacologists; optometrists; cellphone and molecular biologists and biochemists; retinal experts; AMD researchers; and graduate and clinical college scholars in those disciplines.

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Ultrastructurally, hard drusen contain membrane-bound bodies that are found in what Sarks and associates have described as “entrapment sites,” in which coated, membrane-bound bodies are “trapped” between the RPE basement membrane and the inner collagenous layer of Bruch’s membrane (2). This material is currently presumed to derive from the RPE (5). 15 16 Zamir and Rao Figure 1 A hard druse. A globular hyaline deposit with overlying RPE atrophy. The retina is artifactually detached, thus not shown in this picture (H&E).

Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 1989;30:1691–1699. 76. Burke JM, Skumatz CMB. Autofluorescent inclusions in long-term postconfluent cultures of retinal pigment epithelium. Invest Ophthalmol Vis Sci 1998;39:1478–1486. 77. Wassell J, Ellis S, Burke J, Boulton M. Fluorescence properties of autofluorescent granules generated by cultured human RPE cells. Invest Ophthalmol Vis Sci 1998;39:1487–1492. 78. Beatty S, Koh H, Phil M, Henson D, Boulton M.

Sparrow JR, Parrish CA, Hashimoto M, Nakanishi K. A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Invest Ophthalmol Vis Sci 1999;40:2988–2995. 82. Rawes V, Kipling D, Kill IR, Faragher RG. The kinetics of senescence in retinal pigmented epithelial cells: a test for the telomere hypothesis of ageing? Biochemistry (Mosc) 1997;62:1291–1295. 83. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Hartley CB, Shay JW, Lichtsteiner S, Wright WE. Extension of life-span by introduction of telomerase into normal human cells.

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Age-Related Macular Degeneration by Jennifer I. Lim

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